Published IRF-Supported Research

1.  Bell SJ and Sears B. Low-glycemic load diets: Impact on obesity and chronic diseases.  Crit Rev Food Sci Nutr 43:357-377 (2003)

2.  Bell SJ and Sears B.  A proposal for a new national diet:  A low glycemic-load diet with a unique macronutrient composition.  Metabol Synd Related Disord 1:199-208 (2003)

3.   Bell SJ and Sears B.  The Zone diet: An anti-inflammatory, low glycemic-load diet.”  Metabol Synd and Related Disord 2:24-38 (2004)

4. Johnston CS, Tjonn S, Swan PD, White A, Hutchins H, and Sears B.  Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.  Am J Clin Nutr 83:1055-1061 (2006)

5. Johnston CS, Tjonn SL, Swan PD, White A, and Sears B.  Low-carbohydrate, high-protein diets that restrict potassium-rich fruits and vegetables promote calciuria.  Osteoporos Int 17:1820-1821 (2006)

6. Johnston, CS, White AM, Tjonn, S, Swan PD, Hutchins H, and Sears B.  Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Reply to NJ Krilanovich.  Am J Clin Nutr 85:239 (2007)

7. Sorgi PJ, Hallowell EM, Hutchins HL, and Sears B.  Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. Nutr J 13:16 (2007)

8. White AM, Johnston CS, Swan PD, Tjonn SL, and Sears B.  Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: A pilot study.  J Am Diet Assoc 107:1792-1796 (2007)

9.  Sears B.  Anti-inflammatory diets for obesity and diabetes.  J Coll Amer Nutr 28:482S-491S (2009)

10.  Mills JD, Bailes JE, Sedney CL, Hutchins H, and Sears B.  Omega-3 dietary supplementation reduces traumatic axonal injury in a rodent head injury model.  J Neurosurgery 114:77-84 (2011)

11.  Sears B and Ricordi C.  Anti-inflammatory nutrition as a pharmacological approach to treat obesity. J Obesity 2011:431985 (2011)

12.  Sears B and Ricordi C.  Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.  Eur Rev Med Pharmacol Sci 16:1137-1154 (2012)

13.  Lotrich, FE, Sears, B, and McNamara RK.  Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: Relationship with interleukin-6.  Brain, Behavior, and Immunity 31:48-53 (2013)

14.  Sears B, Bailes J, and Asselin B.  Therapeutic uses of high-dose omega-3 fatty acids to treat comatose patients with severe brain injury.  PharmaNutrition 1:86-89 (2013)

15.  Lotrich FE, Sears B, and McNamara R.K.  Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids.  J Psychosomatic Res 75:475-483 (2013)

16.  McNamara RK, Perry M, and Sears, B.  Dissociation of C-reactive protein levels from long-chain omega-3 fatty acid status and anti-depressant response in adolescents with major depressive disorder:  an open-label dose-ranging trial.  J Nutr Therapeutics 2:235-243 (2013)

17. Georgiou T, Neokleous A, Nikolaou D, and Sears B.  Pilot study for treating dry age-related macular degeneration (AMD) with high-dose omega-3 fatty acids.  PharmaNutrition 2:8-11 (2014)

18.  Sears B and Perry M.  The role of fatty acids in insulin resistance.  Lipids Health Disease 14:121 (2015)

19. Sears B.  Anti-inflammatory diets.  J Am Coll Nutr 34: Suppl 1 14-21 (2015)

20.  Lotrich FE, Sears B, and McNamara RK.  Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk.  Prostaglandins Leukot Essent Fatty Acids 106:19-25 (2016)

21.  Sears B.  High-dose omega-3 fatty acids and vitamin D for preservation of residual beta cell mass in type 1 diabetes.  CellR4 4: e2107 (2016)

22.  Sears B.  Delaying adverse health consequences of aging:  The role of omega-3 fatty acids on inflammation and resoleomics.  CellR4 4: e2111 (2016)

23.  Sears B.  Omega-3 fatty acids and cardiovascular disease:  Do placebo doses give placebo results?  CellR4 5: e2302 (2017)

24.  Sears B.  Polyphenols: Novel applications in human health.  CellR4 5: e2437 (2017)

25.  Johnson CS, Sears B, Perry M, and Knurick JR.  Use of novel high-protein functional food products as part of a calorie-restricted diet to reduce insulin resistance and increase lean body mass in adults:  A randomized controlled trial.  Nutrients 9:1182 (2017)

26.  Davinelli S, Corbi G, Righetti S, Sears B, Olarte HH, Grassi D, and Scapagnini G.  Cardioprotection by cocoa polyphenols and omega-3 fatty acids:  A disease-prevention perspective on aging-associated cardiovascular risk.  J Med Food 21:1-10 (2018)

27.  Sears B.  Omega-3 fatty acids and cardiovascular disease: Dose and AA/EPA ratio determine the therapeutic outcome.  CellR4 6: e2531 (2018)

28.  Infante M, Sears B, Rizzo AM, Mariani Cerati D, Caprio M, Ricordi C, and Fabbri A.  Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review.  Nutr Neurosci 13:1-12 (2018)

29.  Sears B.  Appropriate doses of omega-3 fatty acids for therapeutic results.  CellR4 6: e2578 (2018)

30.  Infante, M, Ricordi C, Baidal DA, Alejandro R, Lonzoni G, Sears B, Caprio M, and Fabbri A.  VITAL study: An incomplete picture?  Eur Rev Med Pharm Sci 23: 3142-3147 (2019)

31.  NaPier Z, Kanim LEA, Arabi Y, Salehi K, Sears B, Perry M, Kim S, Sheyn D, Bae HW, and Glaeser JD.  Omega-3 fatty acid supplementation reduces intervertebral disc degeneration.  Med Sci Monit 14: 9531-9537 (2019)

32.  Bailes JE, Abusuwwa R, Chowdhry R, Schleicher D, Hempeck N, McErlane M, Gandhi YN, Bokhari F, Navarro N, Patel V, and Sears B.  Role of omega-3 fatty acids in outcomes of severe brain trauma:  A case series.  J Neurosurg 15:1-5 (2020)

33. Sears B, Perry M, and Saha AK.  Dietary technologies to optimize healing from injury-induced inflammation.  Antiinflamm Antiallergy Agents Med Chem 20: 123-131 (2021)

34.  Sears B and Saha AK.  Dietary control of inflammation and resolution.  Frontiers Nutr 8:709435 (2021)

35.  Borja-Magno A, Guevara-Cruz M, Flores-López A, Carrillo-Domínguez S , Granados J, Arias C , Perry M , Sears B, Bourges H, and Gomez FE.  Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity:  Eicosapentaenoic and docosahexaenoic acid supplementation.  Front. Nutr. 10:1156995 (2023)

36.  Borja-Magno A, Furuzawa-Carballeda J, Guevara-Cruz M, Arias C, Granados J, Bourges H, Tovar AR, Sears B, Noriega LG, and Gomez FE.  Supplementation with EPA and DHA omega-3 fatty acids improves peripheral immune cell mitochondrial dysfunction and inflammation in subjects with obesity.  J Nutr Biochem  120:109415 (2023)